Tumor Cell Toxicity of Hypericin and Related Analogs¶

Nick J. Wills; Jaehun Park; Jin Wen; Sarathy Kesavan; George A. Kraus; Jacob W. Petrich; Susan Carpenter

doi:10.1562/0031-8655(2001)074<0216:TCTOHA>2.0.CO;2

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Nick J. Wills,¹ Jaehun Park,² Jin Wen,² Sarathy Kesavan,² George A. Kraus,² Jacob W. Petrich,² Susan Carpenter^1,*

¹aDepartments of Veterinary Microbiology and Preventive Medicine
²bChemistry, Iowa State University, Ames, IA

^**To whom correspondence should be addressed at: 1136 Vet Med Complex, College of Veterinary Medicine, S. 16th St., Iowa State University, Ames, IA 50011, USA. Fax: 515-294-8500; scarp@iastate.edu

Abstract

A series of hypericin analogs were found to differ in their cytotoxic activity induced by ambient light levels. These analogs vary in their ability to partition into cells, to generate singlet oxygen as well as in other photophysical properties. The data suggest that the biological activity of hypericin is due to a combination of factors whose roles may vary under different circumstances.

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Nick J. Wills, Jaehun Park, Jin Wen, Sarathy Kesavan, George A. Kraus, Jacob W. Petrich, and Susan Carpenter "Tumor Cell Toxicity of Hypericin and Related Analogs," Photochemistry and Photobiology 74(2), 216-220, (1 August 2001). https://doi.org/10.1562/0031-8655(2001)074<0216:TCTOHA>2.0.CO;2

Received: 13 February 2001; Accepted: 1 May 2001; Published: 1 August 2001

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